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Cedars-Sinai Postdoctoral Scientist - Department of Medicine - Hepatology - Seki Lab in Los Angeles, California

The primary focus of the Seki Laboratory is to understand the role of innate immune and inflammatory signals in chronic liver diseases such as liver fibrosis, alcoholic and nonalcoholic steatohepatitis and hepatocellular carcinoma. In particular, our laboratory is interested in studying the interplay between hepatocytes and non-parenchymal cells (Kupffer cells and hepatic stellate cells) in chronic liver disease. Our research goal is to discover new mechanisms of and novel therapeutic targets for chronic liver disease.

Job Summary:

The Division of Digestive & Liver Diseases at Cedars-Sinai Medical Center is looking for a Postdoctoral Scientist to join a hepatology research laboratory. The laboratory studies the molecular mechanisms of various liver diseases: alcoholic and non-alcoholic fatty liver disease, liver fibrosis, and liver cancer. Additionally, laboratory investigates the growth of metastatic liver tumors and the gut microbiome as it relates to nonalcoholic fatty liver disease.

Working independently but in close cooperation and in consultation with the principal investigator and other Research Scientists, as a Postdoctoral Scientist, you will conduct experiments in various ongoing projects. You will perform laboratory tasks that include, routine and complex laboratory procedures and experiments throughout the training period. You will develop, adapt, and implement new research techniques and protocols as well as analyze and interpret data. You may assist in preparation of grant proposals and will participate in publications and presentations as author or co-author. In this position, you will not responsible for generating grant funds.   

Essential job duties and responsibilities:

  • May assist in preparation of grant proposals, but is not responsible for generating grant funds.

  • May participate in publications and presentations as author or co-author.

  • Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.

  • Develops, adapts, and implements new research techniques and protocols.

  • Analyzes, interprets, summarizes and compiles data.

  • Performs routine and complex laboratory procedures and experiments throughout training period.

  • Operates and maintains laboratory equipment and instruments.

  • Operates standard office equipment.

  • Perform research activities involving live animals (mice).

  • Isolation of different hepatic cell populations and intracellular signaling of hepatic stellate cells, plasmacytoid dendritic cells, liver macrophages, and hepatocytes.

  • Will perform routine cellular, micro- and molecular biology procedures including, but not limited to Western blot, DNA/RNA/protein extraction, genotyping PCR, real time PCR, cell culture, transfection of plasmids, Immunohistochemistry, and staining.

  • Assist with the maintenance and perform genotyping by PCR of mouse colonies.

  • Participate and train in various surgical procedures and non-surgical procedures.

Educational Requirements:

  • Doctorate (PhD, MD/PhD, VMD/PhD, or DDS/PhD) in area directly related to field of research specialization is required

Experience:

  • Works independently on research projects and experiments designed by a mentor (typically the PI) within area of specialization.

  • Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.

  • Demonstrates aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.

  • Knowledge of safety standards and maintenance of specialized equipment.

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.

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