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Cedars-Sinai Postdoctoral Scientist – Novel cell death mechanisms, Cancer Institute in Los Angeles, California

When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it’s just one of the many reasons why we rank as one of the top hospitals by U.S. News & World Report.

Are you ready to be a part of breakthrough research? Apply and join our team!

Dr. Keith Syson Chan’s laboratory is seeking a postdoctoral scientist to investigate non-classical mechanisms of therapy resistance, including but not limited to cell death-induced cancer stem cell repopulation [ Nature 517, 209–213(2015) https://rdcu.be/cikEy ], and immunosuppression [ Nature Communications 11: 6299 (2020) https://rdcu.be/cikEQ ]. This project will build on existing mass spectrometry proteomics data to dissect a novel molecular complex in regulating inflammatory cell death mechanisms, and their connections to downstream biologic processes, e.g., immune regulation.

Ideal candidate will be a self-motivated individual enthusiastic to interact with other lab members and the PI, he/she is most welcome to bring new ideas to drive project directions. Expertise in molecular biology of lytic cell death mechanisms, with extensive experience in molecular biology for analyzing protein-protein interaction, molecular complex formation, CRISPR-Cas9 technology for site specific mutations to disrupt protein domain interaction will be highly preferred. Experience in drug screening platforms will be desirable but not required.

KS Chan lab is comprised of an interdisciplinary team https://www.research4cure.org , focusing on cancer research that can translate into early-phase clinical trials or biomarkers to impact patients. We integrate cutting edge single-cell technologies and various study models (e.g., patient-derived xenografts, syngeneic murine models, GEMM) to address key research questions spanning: i) cell death-induced non-classical mechanisms of therapeutic resistance, ii) primary tumor and metastatic niche, and iii) emerging immunologic concepts that impact tumor progression and immune checkpoint response.

To learn more:

  • https://bio.cedars-sinai.org/chank3/index.html Cedars-Sinai Cancer ranks #7 in the nation

  • https://www.linkedin.com/in/keith-syson-chan-42967411b/

Primary Duties and Responsibilities:

  • The design of research directions and experiments in cooperation with the mentor. Will keep appropriate experimental records and analyze the results with the PI.

  • Explore literatures and state-of-the-art techniques relevant to the project.

  • Compiling figures and text for the submission of publications and presentations as primary author or co-author.

  • Highly encouraged to apply for fellowship or career transition grant application for career advancement.

Education:

  • Doctorate (MD, PhD, VMD, or DDS) in biomedical sciences, cancer biology or biochemistry.

Essential Job Responsibilities

  • Participate and present at lab meetings, research-oriented interest groups, and attend departmental or cancer center seminar series

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.

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