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Cedars-Sinai Postdoctoral Scientist (Telomerase Biology) in Los Angeles, California

The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in the areas of telomerase biology. These contribtuions include finding a high frequency of TERT promoter mutations (Clin Cancer Res. 2014 20(18):4935), the impact of these TERT mutations on TERT expression, and the clinical relevance of these mutations in patients (Science. 2015;347(6225):1006). Further discoveries have been made in TERT regulation (Genes Dev. 2015 29(21):2219). We are seeking a highly motivated individual to further develop this work as well as discover and investigate the role of TERT, its regulators and effectors, in cancer progression and metastasis. In addition, the laboratory has ongoing drug discovery projects directed at key molecules involved in telomerase biology which may interest the individual. The successful candidate will have a PhD degree and background in telomerase biology or related field as well as in functional genomics (including CRISPR, shRNA and cDNA library use), signal transduction and biochemistry/chemistry or related fields. We welcome applications who are completing their PhD as well as individuals seeking additional postdoctoral training. Strong preference will be given to individuals with an outstanding publication record from their prior graduate and/or postgraduate training and/or existing extramural funding.

ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:

May assist in preparation of grant proposals, but is not responsible for generating grant funds.

Participates in publications and presentations as author or co-author.

Designs and performs experiments. Keeps detailed experimental records and documentation and analyze the results with the Principal Investigator.

Develops, adapts, and implements new research techniques and protocols.

Analyzes, interprets, summarizes and compiles data.

Performs routine and complex laboratory procedures throughout training period.

Meets with Dr. Theodorescu on a regular basis to discuss research progress and plans.

May be asked to write small grant proposals or NRSA/T32 applications.

Spends about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research.

Educational Requirements: Doctorate (PhD or MD) in molecular biology, or area directly related to field of research specialization.

Experience: Works independently on research projects within an area of specialization. Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment. Demonstrates aptitude to perform experimental protocols and procedures, including detailed data collection and analysis. Knowledge of safety standards and maintenance of specialized equipment a plus.

Physical Demands: Able to perform moderate lifting. Able to sit, stand and walk for prolonged periods of time. Able to read papers and online documents. Able to operate standard office equipment. Able to exercise physical ability and perspective acuity to satisfactorily perform essential job functions. Duties will require walking throughout the Medical Center.

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.

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