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Cedars-Sinai Project Scientist (Alzheimer's Disease) - Pathology Group Operations - Tourtellotte Lab in Los Angeles, California

The Project Scientist in the role will focus on

studying the role of microglia in Alzheimer’s Disease pathogenesis and evaluating

molecules that can augment microglial function and neurotoxic Amyloid-beta (Ab) processing and homeostasis in the brain. You must hold a doctoral degree (preferably with expertise in microglia biology and

Alzheimer’s disease, but at a minimum with neuroscience, neurobiology,

molecular biology or a closely related field).

The successful candidate should have a minimum of 3 years of experience

as a scientifically productive post-doctoral fellow and must have experience with translational

research using animal models to study mechanisms of gene function and disease

pathogenesis. Experience in molecular

biology, cell culture, immunocytochemistry, Western blotting, PCR, quantitative

real-time PCR and histology/imaging techniques including quantitative

bright-field and fluorescence microscopy and confocal microscopy is required. Experience with proteomics analysis of

isolated protein complexes will be beneficial for some of the planned protein-protein

interaction experiments. Will

be expected to independently design and conduct experiments, collect and analyze

data, troubleshoot experimental protocols, consolidate data for publication and

grant applications, present research at national and international meetings,

and prepare manuscripts for publication. Teaching and supervising other research staff, students, and residents

may be required.

You will work independently and in cooperation with the Principal Investigator to make

significant and creative contributions to the assigned research project. The research projects assigned are developed under the direction and in collaboration with the

Principal Investigator, Warren Tourtellotte, MD, PhD, Professor and Vice-Chair

of Pathology and Laboratory Medicine and Professor of Neurology, Neurosurgery

and Biomedical Sciences. You will be expected to have substantial scientific independence,

organization, creativity and motivation.

A significant track-record of scholarly productivity and strong evidence

of successful independent experimental design and execution is expected and


Summary of Essential Job


  • Will publishresearch as author or co-author, and present progress reports at meetings andseminars.

  • Analyzes, interprets,summarizes and compiles data for publication.

  • Maydevelop, adapt and implement new research techniques and protocols.

  • May assist inpreparation of grant proposals, submissions, publications and presentations,but is not responsible for generating grant funds.

  • May serve as PI forcertain grants as approved by Principal Investigator.

  • May lead or train StaffResearch Associates and Research Fellows.

  • Will assist inday-to-day laboratory activities.

  • Appointees on anacademic trajectory will be expected to commit a portion of their time todeveloping an independent range of research.

Educational Requirements:

  • PhD or highest degree in their field is required


  • Demonstrated significant, original, and creative contributions to a research or creative program or project completion of postdoctoral appointment in area of specialization, as applicable.

  • Completion of postdoctoral appointment in area of specialization, as applicable.Knowledge of PI’s area of research specialization.

  • Demonstrated technical competency in a variety of research techniques and protocols.

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.